Who do you want to play the characters form the comic book. This is what Im thinking. Yorrick - Shia LaBeouf (Indiana Jones 4) http://agentsmithfiles.files.wordpress.com/2008/05/shia-labeouf-gq-june-2008.jpg I think Shia is the best choice. I believe that some of Shia's best work was from "Disturbia", and I think his best performance will be from "Eagle Eye". Both Directed by DJ Caruso.The only other actor who I think could do a good job is Ryan Gosling (Fracture) Agent 355 - Thandie Newton (Crash) http://www.oceleb.com/img/thandie-newton/thandie-newton.jpg To me I think she is the only good choice. Now they could go out and cast someone like Jada Pinkett Smith (Collateral) or Alicia Keyes (Smokin' Aces), but it just wouldnt feel right. Well at least my opinion. Doctor Mann - Michelle Yeoh (Babylon AD) http://images.askmen.com/galleries/actress/michelle-yeoh/pictures/michelle-yeoh-picture-2.jpg Now I actually liked "Babylon AD". I think her performance is what made it bearable to watch. I also think that Yunjin Kim (TVs Lost) could pull off the role, but shes pretty young. Beth - Katie Cassidy (When a Stranger Calls) http://www.thehollywoodgossip.com/images/gallery/katie-cassidy-photo.jpg She looks almost identical to Beth, to me. I was also think Isabel Lucas (Transformers 2), Amber Heard (Pineapple Express), or Rachel Taylor (Transformers).